OVARIAN AND UTERINE CHANGES INDUCED BY BROMOCRIPTINE INJECTION TO PSEUDOPREGNANT RATS
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Abstract
Administration of bromocriptine (100 g) to rats on day 7 of pseudopregnancy (P.P.) caused a marked reduction in P.P. length associated with a significant reduction in ovarian weight and an increase in uterine weight. Structural changes included: a marked increase in the percentage of both antral follicles and atretic corpora lutea, endometrial lining height, stromal and myometrial thickness. The results reaffirm prolactin role in maintaining rat luteal function.
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Bast, J.D. and Melampy, R.M. (1972). Luteinizing hormone, prolactin and ovarian 2 d-hydroxysteroid dehydrogenase levels during pregnancy and pseudopregnancy in the rat. Endocrinology.19: 1499-1505.
Bessor, G.M. and Thorner, M.O. (1976). Bromocriptine in the treatment of the hyperprolactinaemia hypogonadism syndrome. Post-Gradute Med. J. 52 (Suppl. 1):64-70.
Campbell, C.S. and Schwartz, N.B. (1977). Steroid feedback regulation of luteinizing hormone and follicle stimulating hormone secretion rates in male and female rats. J. Toxic. Environ. Heal. 3: 91-95.
Ectors, F.; Dangwy, A. and Pasteels, J.L. (1972). Ultrastructure of organ cultures of rat hypophysis exposed to ergocornine J. Endocrinol. 52: 211-212.
Ganong, W.F. (1985). Review of medical physiology. 12th ed., Lange Medical Publication, California.
Janssens, L.A.A. (1986). Treatment of pseudopregnancy with bromocriptine, an ergot alkaloid. Vet. Record. 119:172-174.
Madjerek, Z.S. (1971). Histological effects of progesterone on the vagina and the uterus.In: International encyclopedia of pharmacology and therapeutics, Sec. 48, vol. I, Pergamon press, Oxford, pp. 65-82.
Malven, P.V. (1969). Luteotrophic and luteolytic responces to prolactin in hypophysectomized rats. Endocrinology. 84: 1224-1229.
McDonald, L.B. (1975). Veterinary endocrinology and reproduction, Lea and Febiger, Philadelphia, Pennsylvania.
Meites, J.; Lu, K.H.; Wuttke, W.; Welsch, C.W.; Nagasawa, H. and Quadri, S.K. (1972). Recent studies on functions and control of prolactin secretion in rats. Rec. Prog. Horm. Res. 28: 471-526.
Shaik, A.A. and Yoshinaga, K. (1970). Prolongation of pseudopregnancy in rats by LH.. Biol. Repord. 3: 31-34.
Shedecor, G.W. and Cochran, W.G. (1967). Statistical methods. 6th ed., The Iowa State College Press, Ames., Iowa.
Uilenbroek, J.Th. J. and Linden, R. Van der (1984). Effects of prolactin on follicular oestradiol production in the rat. J. Endocrinol. 102: 245- 250.
Welschen, R.; Osman, P.; Dwllaart, J.; Greep, W.J.: Uilenbroek, J. Th.J. and Jong, F.H. (1975). Levels of follicle stimulating hormone, luteinizing hormone, oestradiol -17 B and progesterone, and follicular growth in the pseudopregnant rat. J. Endocrinol. 64: 3-47.
Wuttke, W. and Meites, J.(1972). Induction of pseudopregnancy in the rat with no rise in serum prolactin. Endocrinology. 90: 438-443.