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Resveratrol (RS) is widely used in medical fields as an antioxidant. Current research investigated the protective role of RS supplement on histomorphometric and histopathological alterations in testes were caused by hydrogen peroxide (H2O2) of rats as an animal model. Thirty-two adult rats were utilized in this study, divided randomly into 4 equal groups as follows. The group C was given tap water only and served as control, the 2nd group (G1) was given 0.5% of H2O2 of tap water, the 3rd group (G2) was given tap water containing 0.5% of H2O2 and intubated RS supplement at 87 mg/kg BW, and 4th group intubated RS supplement 87 mg/kg BW. after 56 days of treatment, rats were euthanized, dissected then, specimens of testes tissue were collected for histomorphometric and histopathological evaluation. Our results showed that administration of H2O2 caused a significant histomorphometric with histopathological changes in the form of a thickness of fibrous tunica albuginea, disarrangement of germ cells, necrosis of spermatogonia, edema, and loss of sperms as compared to other groups. Meanwhile, these histological alterations were partially attenuated in the G2 group that intubated resveratrol. Thus, the current study concluded that resveratrol may have therapeutic value in the treatment of induced testicular injury by H2O2 due to its antioxidant activity and attenuation of harmful effects of oxidative stress through a mechanism that should be elucidated in future studies.
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