Experimental diabetic nephropathy in rats injected with alloxan
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Abstract
The present investigation aimed determenation of diabetic nephrepathy in alloxan treated rats. The study included:
- Seruim chemical studies.
- Histopathological and histochemical study on the kidney glomeruli.
Thirty white male rats were used. They were randomly allocated into 3 groups. Izgroup was injected with alloxan monohydrate for 30 days:
2nd group was fed 1% cholesterd lie and injection of 38 mg/kg B.W alloxan dialy for 30 days; 3rd group was normal diet.
kept on
Blood glucose and total Serum cholestered in 1 and 2 groups significantly increased at day 10, 20, 30.
Glomerular lesion in 1 and 2 groups were found, characterized by dilation of glomeruli which showed lipid accumulation.
In conclusion, hyperlipidemia accompanying hyperlipidemia in alloxan induced hyperglycemia, in part apossible factor in the pathogenesis of diabetic nephropathy.
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ALKaisie, B. I. M. (1992) The pathogentic role of hyperlipidemia in experimental diabetic, glomeruloselerosis. college of Vet. Medicine Baghdad. Athesis.
Cohen, M. P., Surma, M. L. and Wu, V. Y. (1982). Invivo biostynthesis and tumover of glomerular basement membrance in diabetic rats. Am. J. physiol., 242, F95.
Dworkin, L. D., Hosteter, T. H., Rennke H. G. and brenner, B. M. (1984) Hemodynamic basis for glomerular injury in rats with desoxyxorticiosterone salt hypertension. J. clin. Invest., 73:1448.
Huang, T. W. (1980) The nature of basal Lamina alterations in human diabetic glomerulosclerosis. A. J. path.,
, 225- 233.
Kostner, G. M. and Karadi, 1, (1988) Lipoprotein alteration diabetes mellitus. Diabetolog., 31: 717-722.
Lenzen, S: and Panten, U. (1988) alloxan; History mechannism of action. Diabetolog 31: 337-342.
Nobert, W. T. (1987) Tex book of clinical chemistry; 793-794.
Sebai, Z. A. (1987) diabetes mellitus in saudi Arabia. post graduate doctor., 10(10); 582-593.
Strong, J. A. and Baird J. D. (1972) Disease of the endoerine system. In: Davidson. S. S. and Macleod, S. (eds). Principles and Practice of Medicine: 10 th, edition. Churchill Livingstotne Edinburg.
Wilens. S. L. and Stumpf, H. H. (1955) nodular and fatty glomerular lesion in rabbits on cotisone. Am. J. path; 34:275-287.
Who, Report(1985) WHO study group on diabetes mellitus. 12. Zak, B.(1957) simple rapid microtechnique for serum total
chlesterol. Am. J. clin. path., 27: 583.
Zavaroni, E. Dell Aligo, C. and Buttrini (1981) Effect of metformin on dietary-induced hypertriglyceridemia in the rat : 155-160 diabetes.