A Comparison Between The Pharmacokinetics Of Gentamicin And Its Mixture With Calcium In Rabbits
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Published:
Jun 28, 2004
Keywords:
Calcium, Rabbits, Gentamicin
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Abstract
Pharamcokinetic studies were performed for gentamicin sulphate at single dose of 5 mg/kg compared with formullae of same dose of gentamicin with calcium gluconate at a dose of 7.5 mg/kg injected i.v. and i.m. to four groups of 5 rabbits. The results of i.v. injection showed elimination of first order two compartment model with lower plasma gentamicin concentration, lower inhibition bacterial period and increase of gentamicin clearance in mixture group may be due to its competition with calcium for albumin which increase the free drug available for excretion and distribution while after i.m. injection absorption of gentamicin from formullae was lower but its plasma elimination (B) was slower with nearly same inhibition bacterial period as in gentamicin dosed group. These results explain kinetically why calcium lower gentamicin toxic side effect after i.m. and i.v. injection.
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A Comparison Between The Pharmacokinetics Of Gentamicin And Its Mixture With Calcium In Rabbits. (2004). The Iraqi Journal of Veterinary Medicine, 28(1), 214-226. https://doi.org/10.30539/ijvm.v28i1.1079
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How to Cite
A Comparison Between The Pharmacokinetics Of Gentamicin And Its Mixture With Calcium In Rabbits. (2004). The Iraqi Journal of Veterinary Medicine, 28(1), 214-226. https://doi.org/10.30539/ijvm.v28i1.1079
References
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7. Tange, R.A.; Dreschler. W.A; Prins, J.M and Buller. H.R. (1995). "Ottoxicity and nephrotoxicity of gentamicin Vs. Netilimicin in Patients with serious infections. Randomized clinical trial. "Clin otolaryngol. 20(2) pp 118-123.
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10. Gang , S.K. , Verma, S.P., and Uppal, R.P. (1995). " Pharmcokinetics of gentamicin following single-dose paranteral adminstration to goats. " Br. Vet. J. 151(4) pp 453-8
11. Swan, G.E. ; Guthrie , A. J. ; Mulder's, M.S. ; Killeen, V.M. (1995) "single & Multiple dose pharmcokinetics of gentamicin adminstrated intravenously & intramuswlarly in adnt conditioned throughtred mares. J.S. Afr. Vet. Assoc. 66(3)p 151-6.
12. Martin-Jimenez, T., Papich, M and Riviere, J. (1997). " Population pharmcokinetic of gentamicin in horses. " J. Vet. Pharmacowl. Therap. 20(1) pp 21-86
13. Dorothy , J.D. Anne N.N. & Joseph , S. (1997). " Pharmcokinetics of gentamicin at traditional versus high doses impication for one daily amonoglycoside dosing · Autimicrob. Agent and chemother. 1115-9
14. David , H , Malinee , S. (1984), " calcium is acompetetive inhibitor of gentamicin renal membrane binding . Calcium supplementation protect against gentamicin nephrotozicity. " J. Clin. Invest. 73 pp 134-47
15. Nougnefad , p,; Dehpour, A. R. ; Samadian, T. ; Amini, S. (1994). " Vltrastructural localazation of calcium in neuromuswlar junction of smooth & skeletal muscles after aminoghy . 9(3), pp 555-61
16. Ernest , J. (1983). " Aminoghycoside and polymyxines " Cited in : basic and clinical pharmacology. Middle east ed. Califormia : lange medical publication's pp501-5
17. Rubinstein, E., Beer - Gehler, G. ; Dubner, J. ; Hallynek , T. (1978) " Amikacin in human biliary tract." current chemotherapy Am. Svc. For microbial . Washington 18-23 pp 998
18. Gasserett & Doulls toxiclogy, (1986)" Distribution , Excretion and absorption of toxicants." 3rd ed New York : Macmillan publishing company pp 50-5
19. Ubaid ,KA , Abbas , DA, Metabolic , biochemical and histopathological studies to explore the calaium role in antagonizing gentamicin toxic side effect in rats, The veterinarian ( In press ).,2004.
2. Siegenthaler; Walter, E; Benetti, A and Luthy, R. (1986) Aminoglycoside antibiotics in infections disease: an overview. Am. J. Med. 80 (Suppl.613) pp 2-14.
3. Huber W. (1988). " Aminoglycosides, Macrolids, Lincosamides, Polymxins, Chlormphemicol and other antibacterial drugs "In : veterinary pharmacology McDonald . L.E> : Iowa state university press pp 822-832.
4. Anne-Marie, G.: Arden, F. Ralph, G. (1971) "pharmacokinetics of gentamicin, Distribution & plasma renal clearance". J. infect. Dis. (124) pp 570-576
5. Ogeden, L. ; Wilson C.H and Colby , E.D. (1995) ". Pharmacokinetics of gentamicin in rabbits." J. Vet. Pharmacol. Therap. 18 pp 156-159.
6. Hottendorf, G. H.; Bornett, D ; Gordon , L.L. and Christensen, E.F.(1981) "Non parallel nephrotoxicity dose-response curves of aminoglycosides " Antimicrob. Agents & Chemother. Pp 1024 1028.
7. Tange, R.A.; Dreschler. W.A; Prins, J.M and Buller. H.R. (1995). "Ottoxicity and nephrotoxicity of gentamicin Vs. Netilimicin in Patients with serious infections. Randomized clinical trial. "Clin otolaryngol. 20(2) pp 118-123.
8. Puljevic, D, and Gasparovic, V. (1995) " Effectiveness and adverse effects of single daily dose of gentamicin Vs twice daily administration " Lijec. Vjesn. 117 (1-2) pp 33-38.
9. Curl , 31 and Curl , J.S. (1988). " Pharmcokinetic of getamicin in laboratory rabbits. -Am. J of Vet. Res. 49, pp 2065-7
10. Gang , S.K. , Verma, S.P., and Uppal, R.P. (1995). " Pharmcokinetics of gentamicin following single-dose paranteral adminstration to goats. " Br. Vet. J. 151(4) pp 453-8
11. Swan, G.E. ; Guthrie , A. J. ; Mulder's, M.S. ; Killeen, V.M. (1995) "single & Multiple dose pharmcokinetics of gentamicin adminstrated intravenously & intramuswlarly in adnt conditioned throughtred mares. J.S. Afr. Vet. Assoc. 66(3)p 151-6.
12. Martin-Jimenez, T., Papich, M and Riviere, J. (1997). " Population pharmcokinetic of gentamicin in horses. " J. Vet. Pharmacowl. Therap. 20(1) pp 21-86
13. Dorothy , J.D. Anne N.N. & Joseph , S. (1997). " Pharmcokinetics of gentamicin at traditional versus high doses impication for one daily amonoglycoside dosing · Autimicrob. Agent and chemother. 1115-9
14. David , H , Malinee , S. (1984), " calcium is acompetetive inhibitor of gentamicin renal membrane binding . Calcium supplementation protect against gentamicin nephrotozicity. " J. Clin. Invest. 73 pp 134-47
15. Nougnefad , p,; Dehpour, A. R. ; Samadian, T. ; Amini, S. (1994). " Vltrastructural localazation of calcium in neuromuswlar junction of smooth & skeletal muscles after aminoghy . 9(3), pp 555-61
16. Ernest , J. (1983). " Aminoghycoside and polymyxines " Cited in : basic and clinical pharmacology. Middle east ed. Califormia : lange medical publication's pp501-5
17. Rubinstein, E., Beer - Gehler, G. ; Dubner, J. ; Hallynek , T. (1978) " Amikacin in human biliary tract." current chemotherapy Am. Svc. For microbial . Washington 18-23 pp 998
18. Gasserett & Doulls toxiclogy, (1986)" Distribution , Excretion and absorption of toxicants." 3rd ed New York : Macmillan publishing company pp 50-5
19. Ubaid ,KA , Abbas , DA, Metabolic , biochemical and histopathological studies to explore the calaium role in antagonizing gentamicin toxic side effect in rats, The veterinarian ( In press ).,2004.