Evaluation of Proteus vulgarisfimbriae antigen by delayed type hypersensitivity (DTH)-skin test in rabbits

Abstract

The aim of this study is to evaluate the use of fimbriae antigens for immunization of rabbits against Proteus vulgaris bacteria results showed a higher significant difference (P<0.05) in erythema diameters in the immunized groups in compared with the control. There was no significant difference between both immunized groups 200 μg/ml and 100 μg/ml after 24 hours. Also, a higher significant differences (P<0.05) in the diameter of induration is recorded in both immunized groups compared to control site, a higher significant differences (P<0.05) in the immunized group (100 μg/ml) at the concentration 200 μg/ml compared with 100 and 50 μg/ml after 24 hours, as follow as after 48 hours except significant differences between 200 and 100 μg/ml concentration (P<0.01) and increase induration after 72 hours between both immunized groups; within groups and control site. Conclusion that the fimbrial antigen have the ability to elicit cellular immune response by delayed type hypersensitivity (DTH).