STUDY THE EFFECT OF ADENOSINE DEAMINASE ENZYME IN INDUCES CYTOGENETIC AND HISTOPATHOLOGICAL CHANGES IN RATS SKIN AND EYES TREATED WITH SUMICIDIN
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Published:
Dec 28, 2000
Keywords:
ADENOSINE, ENZYME, CYTOGENETIC, HISTOPATHOLOGICAL, RATS, SUMICIDIN
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Abstract
The present investigation aimed to study the Adenosine Deaminase activity in induction Cytogentic and histopathological change in skin and eyes of sumicidine treated rats. The study Included. 1-Adenosine deaminase activity . 2-Total serum protein. 3-Micronuclei in binucleated cell. 4-Histopathological changes in skin and eyes.
19 white male rats were used . They are randomly allocated into 3 groups : 1st group was fed 2% sumicidine for 15 days. 2nd group was fed 2% heating sumicidine for 15 days . 3rd group was kept on normal diet. Blood Adenosine Deaminase activity and Total serum protein in 1 and 2 group significantly decreased at 15 and 30 days of treated. The results
indicated that sumicidine increased significantly micronucleus in group 1 and 2. Multifocal granulomatous lesions in skin & eyes of group 1 and 2 were found characterized by highly aggregation of cells (Lymphocytes, Macrophages, Foreign body giant cells and fibroblasts).
In conclusion , Sumicidine even heated accompaying in decreased in decreased Adenosine Deaminase activity and total serum protein , in part a possible factor in the cytogenetic effect and accompanying granuloma formation in skin and eye .
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Al-Qaisi, B. I. (2000). STUDY THE EFFECT OF ADENOSINE DEAMINASE ENZYME IN INDUCES CYTOGENETIC AND HISTOPATHOLOGICAL CHANGES IN RATS SKIN AND EYES TREATED WITH SUMICIDIN. The Iraqi Journal of Veterinary Medicine, 24(2), 88-111. https://doi.org/10.30539/ijvm.v24i2.1169
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How to Cite
Al-Qaisi, B. I. (2000). STUDY THE EFFECT OF ADENOSINE DEAMINASE ENZYME IN INDUCES CYTOGENETIC AND HISTOPATHOLOGICAL CHANGES IN RATS SKIN AND EYES TREATED WITH SUMICIDIN. The Iraqi Journal of Veterinary Medicine, 24(2), 88-111. https://doi.org/10.30539/ijvm.v24i2.1169
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References
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5-Balasem , A.N. and Ali, A.S. (1991) Establishment of dose- response relationships between doses of CS 137 y- 137 y- rays and frequencies of micronuclei in human peripheral blood lymphocytes- Mut. Res. 259:133-138
6-Blaese, R.M. and Culveri, K.W. (1992) Gene therapy for primary Immunodefficiency disease. Immunodefic.Rev. 3: 329-349.
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11-Giblett, E.R., Anderson, J.E., Cohen, F. pollara, B and Meuwissen, H.J. (1972) Adenosine - deaminase deficiency in two patients with severely Impaired cellular Immunity. Lancet ,. 2, : 1067-1069.
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15-Kelly, F. and Sambrock, J. (1973) Differential effed Cytochalasin B. in normal and transformed mouse cell Nature, London, 242: 217-219.
16-Kolmodin – Hedman, B., Swensson , A. and Akerblom, M. (1982) Occupational exposure to some synthetic pyrethroids (permethrin and fenvalerate ). Arch. Toxicol., 50: 27-33.
17-Laufer, J., pellate ,M. & Sattelle. D.B.(1985) Action of pyrethroid insecticides on insect axonal sodium cannels. Pestic. Sci., 16:651-661.
18-Le Quesne, P.M., Maxwell, J. c. and Butterworth, S.T.G. (1980) Transient facial sensory symptoms following exposure to synthetic pyrethroids. Aclinical and electrophysiological assessment Neurotoxicology, 2: 1-11.
19-Okuno, y, Seki; T., ito, S., Kaneko, H.; Watanabe, T.; Yamada, T. and Miyamoto, J. (1986) Differential metabolism of fenvalerate and granuloma formation. II. Toxicological significanis of Lipophilic conjugate from fenvalerate . Toxicol. Appl. Pharmacol ., 83:157-169.
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21-Smyth, J.F. and Harrap, K.R. (1975) Adenosine deaminase activity in Leukaemia . Br. J. Cancer., 31: 544-549.
22-Suzuki , and Mijamoto . J. (1977) studies on mutagenicity of some pyrethroids on salmonella strain in the presence of mouse hepatic fraction. Toxical. Appl. Pharmacol., 63: 170-182. 23-Varley , M.A.; Growenlock, A. H. and Bell M. (1980) " practical clinical biochemisty , 5 th Edn. william Heineman Medical books Itd London.
24-World Health Organization (WHO) (1990) Environmental health criteria 95, Fenvalerate, Geneva .
2- ماجستير ، كلية الطب البيطري - جامعة بغداد الراوي ، هاني منيب محمد أمين . (1997) تأثير الجمع التجريبي بديدان - لثلاث سلالات من الأغنام المحلية والمضربة . رسالة H. Contortus .
3-العمر ، مفتی عبد الرزاق . (1997) تقيم الحالة البيئية للمركبات الكلورية العضوية في البيئة والغذاء . أبحاث البيئة والتنمية المستدامة . مجلد (1) العدد (5).
4-Amer, S.M. and Abaul ela, E.(1985) Cytogenetic effect of pesticides III induction of micronuclei in mouse bone marro by the insecticides Cypermethrin
and roten one . Mut. Res. Iss: 135-142.
5-Balasem , A.N. and Ali, A.S. (1991) Establishment of dose- response relationships between doses of CS 137 y- 137 y- rays and frequencies of micronuclei in human peripheral blood lymphocytes- Mut. Res. 259:133-138
6-Blaese, R.M. and Culveri, K.W. (1992) Gene therapy for primary Immunodefficiency disease. Immunodefic.Rev. 3: 329-349.
7-Briggs, G.G. (1985) Physical properties and environmental behavior of pyrethroids pestic .Sci., 16: 193-194.
8-Buterworth, S.T.G. and Carter, B.L. (1976) Toxicity studies on the insecticide WL43 775 : Acute oral toxicity and neuro pathological effect in rat .
9-FAOI WHO (1980) 1979 evaluations of some pesticide residues in food , rome. Food and Agriculture organzation of united Nation, paper 20.
10-Fenech, M. and Morley, A. (1985) Measurment of micronuclei in lumphocytes Mut. Res., 147:29-36.
11-Giblett, E.R., Anderson, J.E., Cohen, F. pollara, B and Meuwissen, H.J. (1972) Adenosine - deaminase deficiency in two patients with severely Impaired cellular Immunity. Lancet ,. 2, : 1067-1069.
12-Giusti, G. (1981) Adenosine deaminase . in « Methods of enzymatic analysis «Vol.2., 2nd ed . (Bergmeyer, H.U.ed.) PP. 1092- 1099. Verlag chemic International.
13-HILL, I.R. (1985) pyrethroid residues in soil and aquatic environments. pestic. Sci., 16: 196-197.
14-Juma, A.S. (1993) Cytogenetic studies on mice infeced with secondary hydatid disease. M. sc. thesis, Saddam college of medicine Baghdad, Iraq.
15-Kelly, F. and Sambrock, J. (1973) Differential effed Cytochalasin B. in normal and transformed mouse cell Nature, London, 242: 217-219.
16-Kolmodin – Hedman, B., Swensson , A. and Akerblom, M. (1982) Occupational exposure to some synthetic pyrethroids (permethrin and fenvalerate ). Arch. Toxicol., 50: 27-33.
17-Laufer, J., pellate ,M. & Sattelle. D.B.(1985) Action of pyrethroid insecticides on insect axonal sodium cannels. Pestic. Sci., 16:651-661.
18-Le Quesne, P.M., Maxwell, J. c. and Butterworth, S.T.G. (1980) Transient facial sensory symptoms following exposure to synthetic pyrethroids. Aclinical and electrophysiological assessment Neurotoxicology, 2: 1-11.
19-Okuno, y, Seki; T., ito, S., Kaneko, H.; Watanabe, T.; Yamada, T. and Miyamoto, J. (1986) Differential metabolism of fenvalerate and granuloma formation. II. Toxicological significanis of Lipophilic conjugate from fenvalerate . Toxicol. Appl. Pharmacol ., 83:157-169.
20-Parker, C.M.; Wimberly , W.C.; Lam, A.S.; Gardiner, T.H. and Vangelder, G.A.(1986) Subchronic feeding study of decarboxy fenvalerate in rats J. Toxicol. Environ. Health, 18: 77-90.
21-Smyth, J.F. and Harrap, K.R. (1975) Adenosine deaminase activity in Leukaemia . Br. J. Cancer., 31: 544-549.
22-Suzuki , and Mijamoto . J. (1977) studies on mutagenicity of some pyrethroids on salmonella strain in the presence of mouse hepatic fraction. Toxical. Appl. Pharmacol., 63: 170-182. 23-Varley , M.A.; Growenlock, A. H. and Bell M. (1980) " practical clinical biochemisty , 5 th Edn. william Heineman Medical books Itd London.
24-World Health Organization (WHO) (1990) Environmental health criteria 95, Fenvalerate, Geneva .