Toxic changes in some organs of rats exposed to hypervitaminosis A during different gestation period

Abstract

Forty females albino rats divided into four groups, three of them (T1, T2,
T3) dosed orally with 10000 IU Vitamin A according to different gestation
periods while the fourth group dosed with distilled water and considered as
control (C). Statistical changes in the weight of different treated groups organs
were observed specially in the T3 group that represent period of major organofunctional
development and minor organogensis. Also the histopathological
study revealed sever liver necrosis and sever pulmonary hyperplasia in T1
group. Also there was subcutaneous abdominal tumor (fibroma) noticed in one
female of T2 group. We concluded from our results that high dose of vitamin A
may cause cellular, histological and functional defects with possible cryogenic
effect in some internal organs and tissue.