The impact of Levamisole on Newcastle disease antibodies titer in broilers fed with diet contaminated with Aflatoxin

Abstract

This study designed to know the immuno suppressor effect of aflatoxins
and the efficacy of levamisole to reduce these effects in the titer of antibodies
and protection against challenge for Newcastle disease vaccine in chickens.
This trail include three groups, first group fed on ration free from
aflatoxins contamination, Second group fed on ration contaminated with
aflatoxins, while the third group fed on the same ration of second group and
given levamisole via drinking water with the dose of 10mg/kg of body weight.
All groups vaccinated twice against Newcastle disease at 10 and 20 days
of age. The immunity evaluated by ELISA test at 6, 19, 31 days of age and
challenged at 32 days old.
The results indicate that the second group has the lowest titer of
antibodies and protection ratio after challenge, while the first group has the
hightest titer of antibodies and high protection ratio after challenge. The titer of
antibodies and the protection against challenge in the third group had higher titer
than them at second group and lower than them at first group.
These results revealed the role of aflatoxins in immunosuppression for
Newcastle vaccines and reduce the efficacy of vaccination process and reduce
the protection ratio after challenge, also reveal the role of levamisole in reducing
of these effect and elevation of immune response to Newcastle vaccine in
chickens.