Biochemical and Haematological Study in Rats Exposed to Cadmium Chloride in Drinking Water HanaaA.A and Bara N.AL-Ekelly,

Abstract

The objective of this study was investigate the Physiological effect of
different concentrations of cadmium chloride in drinking water on some
biochemical and haematological parameters of male rats. Animals in this
experiment were randomly divided into four equal groups and treated for 15
weeks as follows : Rats in control group were offered ordinary tap water ,
while animal in M1 , M2 , and M3 were received 10 , 20 , 30 ppm Cdcl2 in
drinking water, respectively. The activity of Alanine aminotransferase
(ALP), Aspartate aminotrasferase (AST) and alkaline phosphatase (ALP) in
serum were measured. Further mor, hemoglobin concentration (Hb) and
white blood cells count (WBCs) were detected. The result revealed that
addition of cadmium chloride in different concentrations in drinking water
caused a significant increase in activity of serum of ALT in treated group
(M1 , M2 , M3 ) as compound with control. Within the time the activity of
serum AST was significantly increased in three treated group as compared
with pretreatment period. On the other hand , significant increase in serum
ALP concentration were show in both M1 and M3 treated groups at 12th and
15th week of the treatment as compared with control group. Significant
decrease in haemoglobin concentration were observed in M1 , M2 , M3 from
9th week to the end of experiment comparing to control. While cadmium
chloride treatment caused significant increase in total white blood cells count
in treated groups as compared with control group. On Conclusion, it seems
likely that exposure of male rats to cadmium chloride at level above the
permissive one had induced clear biochemical and haematological changes.