Study the pathological and Residual Toxic effect of Malathion in Mice Nervous System

Abstract

In present experiment , study was done on the pathological and residual effect of malathion in mice 50 white mice randomly divided into 3 group : 1^st group including (20)mice was given single oral dose .1.5 ppm in drinking water 2^nd group contain (20) mice given single dose 1.5 ppm malathion orally in drinking water and repeated the same dose at 2^nd and 3^rd week i.e (three repeated doses), the 3^rd group (10) mice act as control group .The long of experiment was 60 days , the following parameter were done .

1- Clinical Signs: treated group 1^st and 2^nd groups showed nausea and diarrhea

2- Pathological changes : 1^st and 2^nd group showed lesion which were more significant in 2^nd group .Pathological changes characterized by neuron necrosis , Brain odema , and mononuclear cell present with spinal cord damage .

3- Residual investigation: which were more significant in 2^nd group at 60 days of treatment, the Malathion residual reach 0.90 ppm in brain and spinal cord.