Experimental infection of Klebsiella pneumoniae in urinary tract of rats and guinea pigs Ibrahim Z.I and Alwaan M.J.

Abstract

This work aimed to study the pathological changes induced in the
urinary organs after infection with K.pneumoniae. Two laboratory female
animal species ,white rat&guinea pig ,were infected by two
routes,ascending (first group) and direct(intra renal-second group).
The infection was examined in different periods through the bacterial
culture of urine & kidney samples as well as the pathological changes
(gross&microscopic) were examined after post mortum.
The resultes of both groups showed a positive bacteriologic culture of
the urine & kidney samples concomitant with the gross and
histopathological changes of the kidneys which revealed different degrees
of inflammation between the two groups as well as within the indivisuals
of the same group, especially the kidney specimens which showed
pyelonephritis in rats & guinea pigs of both infection routes (ascending
and intrarenal