Reproductive Hormonal Evaluation Of Female Mice After Treatment With Pentoxifylline Salema. L. Hassan ; Rajiha, A. Al- Naimi ; Saad S. Al-Dujaily

Abstract

The aim of this study was the assessment of pentoxifylline (PTX) effects on female reproductive
hormones as well the body and reproductive organs. Sixty white mice with approximately same ages
(eight) weeks and body weights were randomly divided into (six.) equal groups 10 mice for each group.
Group 1: Received tap water along the period of experiment and considered as a control group. Animals
of group 2,3,4,5 and 6 were treated with 16 mg (PTX) / Kg B.W. daily for 2,4,6,8 and 10 weeks
respectively. Before and after treatment all animals were weighed, and blood samples were taken for
follicle stimulating hormone (FSH), lutenizing hormone (LH) and Estradiol (E2) hormones analysis.
After post – Mortem examination reproductive organs were excised and weighed. The experiment
revealed that PTX administration caused increase in total body and reproductive organs weights.
Concerning the biochemical tests results revealed elevation in concentration of FSH, LH and E2
hormones especially significant (P<0.001) in treated groups of (8 and 10 wks duration). Compaired
with another animal groups conclusion. Administration of PTX in low dose for 10 weeks has a
significant effect on reproductive hormones. This will influence reproduction and litter size manifested
after mating with untreated males.