Evaluation of general anaesthesia by using Propionylpromazine, Xylazine and Ketamine in rabbits M. J. Eesa ;R. A. Omar ,H. H. Mohammad Nazhat

Abstract

Safe and effective anaesthetic regimens have been described for use in rabbits,
partially because of the susceptibility of this species to fatal respiratory arrest. The
present study was conducted to evaluate the efficacy of anesthetics, analgesics
combinations an anesthesia in twenty five local breed rabbits. Rabbits were injected
intramuscularly by: Propionylpromazine 0.5mg/kg B.W. as premedictation, after
10minutes later Xylazine and Ketamine Hydrochloride at a dose of 20mg/kg,
50mg/kg respectively. The results of the physiological parameters of the control
group at the period of zero time concerning rectal body temperature, respiratory rate,
heart rate were 38.00±0.29 ºC; 96.36 ±3.33bpm; and 147.20±6.46/minutes
respectively. While in treated group at the periods 10, 20, 35, 50, 65, 80 and 95
minutes were 37.76 ±0.61; 37.34± 0.28; 37.00± 0.29; 37.00±0.35; 36.92±0.38;
35.80±0.40; 34.92± 0.53 ºC; 96.36±3.33; 41.00±1.37; 45.00±2.01; 45±2.01;
40.00±1.31; 40.00±1.31; 39.20±1.01 bpm; and 147.20±6.46; 142.00±3.73;
145.00±3.26; 144.48±3.31; 130.00±4.18; 140.00±3.49; 138.68 ±2.93 beats/minutes.
The results of biochemical tests: Glucose, ALP, GPT, GOT in control group (zero
time) were: (137.40±1.97 mg/dl; 53.09±2.13 U/L; 51.48±4.31 U/L; 116.9±09.82
U/L) respectively. And in treated group at the periods (10, 20, 35, 50, 65, 95 minutes
and 24 hours) respectively were 139.60±0.79; 207.60±5.00; 222.20±7.42;
359.20;±18.89; 341.60±15.30; 337.7±76.39 and 199.92±9.14 mg/dl; 39.74±2.74;
42.55±3.29; 39.65±4.13; 42.48±2.62; 56.56±2.16; 47.41±3.61 and 42.84±4.16 U/L;
46.17±3.92 ; 39.34±3.01; 44.69±3.05; 49.98±3.16; 51.65±4.03; 47.22±2.54 and
72.63±4.98 U/L, and 94.72±8.24; 86.22±5.59; 90.82±6.89; 76.65±4.12; 82.70±4.69;
100.6±7.39 and 126.6±7.77 U/L. The conclusion of this study investigate that the
lose of righting reflex was 4.760±0.421 minutes; induction time was 8.44±1.05, the
time to complete muscle relaxation was 3.920±0.321 minutes, surgical time
41.48±2.11 minutes, and recovery time was 45.76±2.43 minutes; in which the
surgical period was enough for the most of surgical interference, while the recovery
period was smooth and short in comparison with another anaesthetic regimen