Evaluate the effect of different doses for grape seed extract in mice Sanaa Kudair A .AL.Jeboory, Eman H.Y.Al Taae and Rajiha A. AL. Naimi

Abstract

The aim of this study was to evaluate the effect of different doses for grape seeds
extract in internal organs of mice. Histopathological, cytogentical and haematological
studies were done to evaluate this effect. The study was done on (24) mice divided into four
groups (6/group) for one month. Group one treated with PBS considered as control
Negative, Group two treated with (100mg/kg B.W.) of grape seed extract, Group three
treated with (200mg/kg B.W.) of grape seed extract, Group four treated with (300mg/kg
B.W.) of grape seed extract. The results showed that (200, 300mg/kg B.W.) cause
significant decrease in hematological, cytogentical parameters and severe histopathological
changes while at dose (100mg/kg B.W.) induce immune pathological response organ with
amelioration of haematological and cytogentical parameters. In conclusion the effect of
grape seed extract was dose dependent that more severe toxicopathological changes
appeared in haemtological, cytogentical and histopathological results at doses (200 and
300mg/kg B.W.) while at dose ( 100mg/kg B.W.) induce immunopathological response
internal organs with amelioration of haematological and cytogentical parameters.