THE EFFECT OF (DMAA), DIMETHYLACETAMIDE ON THE BLOOD OF THE COWS IN VITRO
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Abstract
Monome thy lacetamide (MMAA) and acetamide (AA) cause hemolysis in concentrations above 100
(DMAA), 44 (MMAA) and 40 (AA) mg/ml blood respectively. The effects are double to three times
stronger than after distilled water.
Dimethylation in the animal body after treatment is followed by an increase of the hemolytic activity.
Concentrations after therapeutic use in vivo are as high as the concentration in vitro in hemolysis activity.
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Anschel, J. (1965). Losungamittel und Losungs—vermittler in Injektionen Pharmaz. Ind. 27:783.
Auclair, U. and Hammeau, N. (1964). Toxicite et pharmacologie de deux solvants organiques: la
dimethylacetamide et la dimetkylforma-mide. Compt. Rend. seanc. Soc. Biol. 158:245.
Baker, H. (1968). The effects of dimethylsulfo-xide, dimethylformamide and dimethyl lacet-amide on the autaneous barrier to water in human skin. J. Invest. Dermatol., 50:283.
Bartsch, W.G., Sponer, K., Dietmann and G. Fuchs (1976).Acute toxicity of various solvents in the mouse and rat. Arzneim. Forsch. 26: 1581.
Coujolle, F., Christoph, H.J. amd Heyer, H. (1970).Toxicological studies upon acetamide and its N- methyl and ethyl derivates. Arzmeim. Forsch. 231242.
Christoph, H.J. and Meyer, H. (1971). Klinisches Laboratorium Hirzel Verlag, Leipzig.
Davis, K.B. and Jenner, P.U. (1959). Toxicity of three drug solvents. Toxicol. appl. Rharm. 1:576.
Fielder, H.P. (1971). Lexikon der Hilfsstoffe fur Pharmazie, Kosmetik umd angrenzende Gebiete. Editio Cantor Aulendorf.
Hapke, H.J. (1970). Unbeabsichtigte Arzneimittel wirkung Tierarztl .Umschau 25:163
Horn, H.J. (1961). Toxicology of dimethyl. acetamide. Toxicol. appl. Pharm. 3:12.
Kaemmerer, K. und B. Garthoff (1976). Studien zur pharmakologie von 1,2-propylonglykol. (Besitzt propylenglykol is Schweinemast-futter sedierinde wirkungen 2. Dtseh. tierarztl. Wschr. 83: 242.
Munro, D.D. (1965). Dimethyl acetamide and dimethyl formamide effects on _ percutaneous absorption. Arch. Drmatol., 92:58.
Wiles and Narcisse (1971). The acute taxicity of dimethylacetamide in several animal species. Am.Ind. Hyg. J. 9:539.