PHARMACOKINETIC OF CHLORAMPHENICOL IN CALVES INFECTED EXPERIMENTALLY WITH SALMONELLA TYPHIMERIUM
Article Sidebar
Main Article Content
Abstract
The pharmacokinetic of chloramphenicol was studied in 8 calves .These calves were infected experimentally with Samonella typhimorium The drug was injected intramuscularly at a dose of 50 mg/kg b.w. every 12 hours for a total of 7 injections. The treatment started 48 hours after the appearance of the clinical symptomes (fever, diaheria and dehydration). Blood samples were taken at regular intervals after the 1st and 7th injection and at 12 hour intervals during treatment. Plasma disappearance curves were constructed by which the biological half lives (t1/2s) and volume of distribution (vds) were calculated.
Peak plasma concentrations were 22.57 and 46.46 ug/ml after the 1st and 7th injection respectively. Both occured 3 hours after injection. The concentrations after 12 hours ranged from 5.9 to 21.6 ug/ml. The t 1/2 s were 4.34 and 8.73 hrs and the values of (vd)
were 1.4 and 0.8 1/kg after the 1st and 7th injection respectively.
Downloads
Article Details
How to Cite
References
- Clark, C.H. (1978): Clinical uses of chloramphenicol, Med. vet. Practice. 59: 889.
- Ziv, G., Bogin, E., and Salman, F.G. (1973): Blood and milk levels of chloramphenicol in normal and mastatic ewes after intramuslar administration of chloramphenicol and chloramphenicol
- Godman, L.S., Gilman, A. (1975) The Pharmacological Basis of Therapeutics (5th edition) MacMillian Publishing Co. Inc. New York.
- Pilloud, M. (1973): Pharmecokingtics, plasma protein binding and dosage of chloremphenicol in cattle and horses. Res. Vet. Sci. 15: 231.
- Grove, D.C. and Randel, W.A. (1955): Assay Methods of antibiotic Monograph No. 2, Medical Encyclopedia, Inc.New York
- English, P.B., and Withy, D. (1959) : Serum, urine and tissue levels of chloramphenicol in the horse.
Aust. Vet. J. 35:187.
- Decorte-Baeten, K., and M. Debaoaere(1975): Chloramphenicol plasma levels in horses, cattle, and sheep after oral and intramuscular administration. 2b1. Vet. Med. A.22: 704.
- Sisodia, C.S., Gupta, V.S., Dunlop, R.H. and Radostitis,O.M.(1973): Chloramphenicol concentration in blood and milk of cows following Parenteral administration Cand. Vet. J. 14:187.
- Burrow, G.E., Barto, P.B., and Tripp M.L. (1983): Comprative pharmacokinetics of antibiotics in newborn calves: Chloramphenicol, lincomycin, and tylosin. Am. J. Vet. Res. 44: 1053.
- Sisodia, C.S., Karmer, L.L., Gupta, V.S., Lerner, D.J., and Taksas, L. (1975): A pharmacological study of chloramphenicol in horses. Cand. J. Comp. Med. 39: 216.
- Daws, L. E., Neff, C.A., Baggot, J.D., and Poweres, T.E. (1972): Phrmacokinetics of chloramphenicol in domesticated animals. Am. J. Vet. Res. 33: 2259.
- Khazal, K.f. (1982): Comparision of pharmacokinetic parameter of chloramphenicol in dog using colorimetric gas chromatography and microbiological methods. M.S. Thesis, O.S.U.