Pharmacokinetics of ciprofloxacin in layer chicks
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Published:
Jun 28, 1999
Keywords:
layer chicks, ciprofloxacin
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Abstract
Pharmacokinetics parameters of ciprofloxacin were calculated from constructed plasma disappearing curves (PDC) after oral or i.v. injection of 5mg / kg in two-week old hybird layer · The i.v. PDC indicated a first order biphasic kinetic. The distribution phase was too short to be considered. The parameters of the elimination phase phase indicated that the biological half – life ( t 12) was 3.7 hours and the volume of distribution (Vd) was 1.7 1/kg.
The oral PDC indicated a first order kinetic with a peak plasma level (PPL) of 3.0 ug/ml achieved after 1.75 hours , a t 12 of 2.9 hours and a Vd of 1.7 1/kg . Bioavailability value was 84 +9.7% . Binding of ciprofloxacin to chicken plasma protein was estimated to be 25.4 61.3%.
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Pharmacokinetics of ciprofloxacin in layer chicks. (1999). The Iraqi Journal of Veterinary Medicine, 23(1), 124-133. https://doi.org/10.30539/ijvm.v23i1.1199
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How to Cite
Pharmacokinetics of ciprofloxacin in layer chicks. (1999). The Iraqi Journal of Veterinary Medicine, 23(1), 124-133. https://doi.org/10.30539/ijvm.v23i1.1199
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13-Nouws, J.F.M.; Merius, D.J.; Vree, T.B.; Baars, A.M. &
Laurensen J. (1988). Pharmacokinetics, renal clearance and metabolism of ciprofloxacin following intravenous and oral administration to calves & pigs .
Vet. Quart 10: 211 - 216
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college of veterinary Medicine, University of Baghdad.
2-Label, M.(1988). Ciprofloxacin chemistry, machanism of action , resistance , antimicrobial spectrum, pharmac okinetic , clinical trails & adverse reactions. Pharmac
otherapy. 8: 3- 33.
3-Dan, M., Torossian, K., Weissberg, D. & Kitzes, R. (1993). The penetration of ciprofloxacin into bronchial mucosa, lung parenchyma and pleural tissue after intravenous
administration . Eur. J. Clin. Pharmacol. 44 : 101- 102.
4-Stutman, H.R.; Shalit ,1.; Marks, M.I.; Greenwood, R.; Chartrand, S.A.& Hilman, B.C. (1987). Pharmacokinetic of two dosage regimens of ciprofloxacin during a two week theraputic trail in patients with cystic fibrosis.
A.J.M. 82: 142 – 145.
5-Grove, D.C. & Randel, W.A. (1955) assay methods of antibiotic . Antibiotic Monograph No.2 Medical encyclopedia, Inc. New York.
6-Shargel, L. & Andrew , B.C.(1984). Applied biopharmac eutics and pharmacokinetics. Appleton - Century - Croftss / New York.
7-Davis, B.D. (1943). The binding of sulfonamide drugs by plasma proteins, a factor in determining the distribution
of drug in the body. J. Clin. Invest. 22: 753.
8-Bergan, T.; Thorsteinsson, S.B.; Solberg , R.; Bjornsken, L.; Kolstad, M.I. & Johnsen, S. (1987). Pahamacokinetics of ciprofloxacin: intravenous and increasing oral doses.AJM.82
(supp 4 A): 97 -102.
9-Hoffken, G.; Lode, H.; Prinnzing, G.; Borrel, K. & Koeppe, P.(1985) Pharmacokinetic of ciprofloxacin. Second communication: Distribution to and elimination from tissue and organs following single or repeated administration of C14. Coprofloxacin in albino rats. Arzniem - Forsch, 36 : 1503 – 1510.
10-Munoz, M.J.; Lioveria, P.; Santos, M.P.; Abadia, A.R.; Aramayona, J.J. & Bregante , M.A.(1996). Pharmacoki - netics of ciprofloxacin in sheep after single intravenous
or intramuscular administration . Vet. Quart. 18 : 45-48.
11-Abadia, A.R.; Bregante, M.A.; Saez, M.P.;Aramayona, J.J.;Garcia, M.A.& Fraile, L. (1994) · Interspecies variation pharmacokinetics of enrofloxacin . Methods & Finding in Experimental & clinical pharamacology :16:159.
12-Siefert, H.M.;Maruhn, D. & Scholl, H. (1986).Pharmacok inetics of ciprofloxacin. Second communication: Distribution to and elimination from tissue and organs following single or repeated administration of C14 - ciprofloxacin in rats. Arzeniem – Forshch, 36: 1503 – 1510.
13-Nouws, J.F.M.; Merius, D.J.; Vree, T.B.; Baars, A.M. &
Laurensen J. (1988). Pharmacokinetics, renal clearance and metabolism of ciprofloxacin following intravenous and oral administration to calves & pigs .
Vet. Quart 10: 211 - 216
14-Drusano, G.A.;Standiford, H.C.; Plaisance, K.& Forrest, A. (1986). Absolute oral bioavailibility of ciprofloxacin. Antimicrob. Agents.Chemoth. 30: 444 – 446.
15-Villa R.; Prondini, E.; Calami, F. & Canli, S. (1997). Serum protein binding of some sulphonamides, quinolones and fluoroquinnolones in farm and domestic animals. J veterinary pharmacol. Therap. 20: 34 – 35.