HISTOLOGICAL CHANGES IN THE TESTI OF PURE INBRED SWISS MICE INDUCED BY PERMETHRIN INSECTICIDE
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Published:
Dec 28, 2000
Keywords:
SWISS MICE, PERMETHRIN, INSECTICIDE
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Abstract
Permethrin, is a synthetic insecticide of appreciably low mammalian toxicity, it is especially useful for household purposes. This work aimed to study the gonadotoxic effect of this insecticide in Swiss mice, using two oral doses of 2000 and 3000 mg/kg b. w. for 30 days. The daily dose was 1.66 mg/kg and 2.5 mg/kg of active ingredient of permethrin for group | and group || respectively. The effect was determined by counting the percentage of damaged seminiferous tubules, their average diameter, and the spermatogenesis rate, also the changes in body weight and in testes-to-body weight ratio. Results showed that the insecticide caused significant reduction in body weight, increase in testes weight, as well as testes-to-body weight ratio, seminiferous tubules in treated animals were found to increase in diameter showing low degrees of damage. Nevertheless, spermatogenic activity was almost normal but in descending order, and Leydig cells remained unaffected. It was concluded that permethrin, has a slight gonadotoxic effect at the doses used which may not really affect the fertility of animals at the doses used.
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HISTOLOGICAL CHANGES IN THE TESTI OF PURE INBRED SWISS MICE INDUCED BY PERMETHRIN INSECTICIDE. (2000). The Iraqi Journal of Veterinary Medicine, 24(2), 231-250. https://doi.org/10.30539/ijvm.v24i2.1179
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How to Cite
HISTOLOGICAL CHANGES IN THE TESTI OF PURE INBRED SWISS MICE INDUCED BY PERMETHRIN INSECTICIDE. (2000). The Iraqi Journal of Veterinary Medicine, 24(2), 231-250. https://doi.org/10.30539/ijvm.v24i2.1179
References
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11. IRPTC. ( 1991) Permethrin, vol. 10(2) UNEP, IRPTC Bulletin, 38-40.
12. Lichfield,.M.H. (1983) Characterization of the principal mammalian toxicological and biological actions of synthetic pyrethroids. In;" Miyamoto J and Kearney PC ed. Pesticide Chemistry: human welfare and the environment. II. Natural products". Oxford Pergamon Press. pp, 207-211.
13. IPCS.(1990) Permethrin, Environmental Health Criteria Series, No. 94. WHO, Geneva, 63-64.
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16. Spencer, F.; and Berhance, Z.; (1982) Uterine and fetal characteristics in rats following a post implantational exposure to permethrin. Bull. Environ. Contam Toxicol. 29: 84-88.
17. Steinberger, E.; Ficher, M. and Smith, K.D. (1970) Relation in vitro metabolism of steroids in human testicular tissue the histological and clinical findings. In:Human Testis. E. Rosemberg & C.Paulsen (ed), New York, Plenum,439
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21. Alwachi, S.N. and Balash, K.J.; ( 1988) Induced alteration in spermatogenesis in mature albino mice injected with caffeine. J. Biol. Sci. Res. 19: 457-468.
22. Gomes, W.R. (1970) Chemical agents affecting testicular functions and male fertility in the Testes Vol III Johnson AD, Gomes W.R., and Vandemark N.L., (ed) Academic Press New York. pp 530-533.
23. Krause, W. and Homola, S. (1974) Alteration of seminiferous epithelium and Leydig cells of the rat testis after the application of dichlorvos (DDVP) Bull. Environ. Contam Toxicol. 11: 429-433 .
24. Al-Omar, M.A.; Abbas, A.K. and Al-Obaidy, S.A.(2000) Combined effect of exposure to lead and chlordane on the testicular tissues of Swiss mice. Toxicology Letters 115(1):1-8.
25. Elliott, M.; Janes N.F.; Pulman D.A.; Gaughan L.C.;.Unai T. and Casida J.E. (1976) Radiosynthesis and metabolism in rats of the IR isomers of the insecticide permethrin. J. Agr.
Food chem. 24: 270-276.
26. Gaughan, L.C.; Unai, T. and Casida, J.E. (1977) Permethrin metabolism in rats J. Agric. Food Chem. 25: 9-17.
27. Abernathy, C.O. and Casida J.E.( 1973) Pyrethroid insecticides: Esterase cleavage in relation to selective toxicity. Science 179: 1235
28. Elliott, M.; Janes N.F.; Kimmel E.C. and Casida J.E. (1972) Metabolic fate of pyrethrin I, pyrethrin and allethrin administered orally to rats J. Agr. Food Chem. 20: 300.
2. Baker, P.G. and Bottomley, P. (1982) Determination of residues of synthetic pyrethroids in fruit and vegetables by gas-liquid and high performance liquid gas chromatography Analyst., 107: 206-212.
3. Battelle, (1982) Pesticide programme of research and market planning Part I: Insecticides Geneva Institut Battelle (October 1982).
4. FHO/WHO. (1981) 1980-Evaluations of some pesticide residues in food, Rome Food and Agriculture Organization of the United Nations. pp. 360-393 (FAO Plant Production and
Protection paper 26 sup).
5. FHO/WHO .( 1982) 1981-Evaluations of some pesticides residues in food. Food and Agriculture Organization of the United Nations Rome pp 385 425 (FAO Plant Production and Protection paper 42).
6. Staatz, C.G.; Bloom, A.S.; and Lech, J.J.(1982) A pharmacological study of pyrethroid neurotoxicity in mice. Pestic Biochem Physiol., 17: 287-292
7. Dyck, P.J.; Shimono, M.; Schoening, G.P.; Lais A.C.; Oviatt K.F. and Sparks, M.F.(1984) The evaluation of a new synthetic pyrethroid pesticide (Permethrin) for neurotoxicity J Environ Pathol Toxicol Oncol., 5:109-117.
8. Verschoyle, R.D. and Aldridge, W.N. (1980) Structure-activity relationship of some pyrethrins to rats. Arch Toxicol., 45: 325-229.
9. Lawrence LJ. and Casida JE (1982) Pyrethroid toxicology: Mouse intracerebral structure-toxicity relationship. Pestic Biochem Physiol., 18:9-14.
10. Kolmodin-Heman, B.; Swensson, A. and Akerblom, M. (1982) Occupational exposure to some synthetic pyrethroids (permethrin and fenvalerate) Arch. Toxicol 50: 27-33.
11. IRPTC. ( 1991) Permethrin, vol. 10(2) UNEP, IRPTC Bulletin, 38-40.
12. Lichfield,.M.H. (1983) Characterization of the principal mammalian toxicological and biological actions of synthetic pyrethroids. In;" Miyamoto J and Kearney PC ed. Pesticide Chemistry: human welfare and the environment. II. Natural products". Oxford Pergamon Press. pp, 207-211.
13. IPCS.(1990) Permethrin, Environmental Health Criteria Series, No. 94. WHO, Geneva, 63-64.
14. Ishmael, J. and Litchfield, M.H. (1988) Chronic toxicity and carcinogenic evaluation of permethrin in rats and mice. Fundam Appl Toxicol., 11: 308 -313.
15. Clapp, M.J.L.; Banham, P.B.; Glaister. J.R. and Moyes, A.( 1977) 28 days feeding study in mice (Report No. CTL/P/354) cited in : IPCS: permethrin EHC series No. 94. WHO, Geneva.
16. Spencer, F.; and Berhance, Z.; (1982) Uterine and fetal characteristics in rats following a post implantational exposure to permethrin. Bull. Environ. Contam Toxicol. 29: 84-88.
17. Steinberger, E.; Ficher, M. and Smith, K.D. (1970) Relation in vitro metabolism of steroids in human testicular tissue the histological and clinical findings. In:Human Testis. E. Rosemberg & C.Paulsen (ed), New York, Plenum,439
18. Krogh Derr, S. and Dekker, J. (1979)Alteration of androgenicity in rats exposed to PCBS. Bull. Environ. Contam Toxicol. 21: 43-46.
19. Shinshi, O. and Kogo, H.(1979) Effect of phthalic acid esters on gonadal function in male rats. Bull. Environ. Contam Toxicol. 21: 65-69. 20. Balash, K.J.; AL-Omar, M. and Abdul-Latif, B. M.( 1987) Effect of chlordane on testicular tissues of Swiss mice. Bull. Environ. Contam. Toxicol. 39: 434-442
21. Alwachi, S.N. and Balash, K.J.; ( 1988) Induced alteration in spermatogenesis in mature albino mice injected with caffeine. J. Biol. Sci. Res. 19: 457-468.
22. Gomes, W.R. (1970) Chemical agents affecting testicular functions and male fertility in the Testes Vol III Johnson AD, Gomes W.R., and Vandemark N.L., (ed) Academic Press New York. pp 530-533.
23. Krause, W. and Homola, S. (1974) Alteration of seminiferous epithelium and Leydig cells of the rat testis after the application of dichlorvos (DDVP) Bull. Environ. Contam Toxicol. 11: 429-433 .
24. Al-Omar, M.A.; Abbas, A.K. and Al-Obaidy, S.A.(2000) Combined effect of exposure to lead and chlordane on the testicular tissues of Swiss mice. Toxicology Letters 115(1):1-8.
25. Elliott, M.; Janes N.F.; Pulman D.A.; Gaughan L.C.;.Unai T. and Casida J.E. (1976) Radiosynthesis and metabolism in rats of the IR isomers of the insecticide permethrin. J. Agr.
Food chem. 24: 270-276.
26. Gaughan, L.C.; Unai, T. and Casida, J.E. (1977) Permethrin metabolism in rats J. Agric. Food Chem. 25: 9-17.
27. Abernathy, C.O. and Casida J.E.( 1973) Pyrethroid insecticides: Esterase cleavage in relation to selective toxicity. Science 179: 1235
28. Elliott, M.; Janes N.F.; Kimmel E.C. and Casida J.E. (1972) Metabolic fate of pyrethrin I, pyrethrin and allethrin administered orally to rats J. Agr. Food Chem. 20: 300.