IMMUNOPATHOLOGICAL EFFECT OF SENSITIZED TRANSFER FACTOR ON THE ORGANS OF WHITE MICE AGAINST SALMONELLA TYPHI CHALLENGE INFECTION.
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Abstract
In an experimental study to evaluate the immunopathological effect of transfer factor on the reticuloendothelial organs of white mice and their protection against their challenge infection with Salmonella typhi. The results of this study were showed the followings: 1. Transfer factor recipient group: it was showed an early granulomatous lesions in the liver. Reactive hyperplasia in the T cell regions of the spleen and mediastinal lymph node. The early granulomas were persisted during 7th day and slightly regressed on 14th day postinoculation. 2. Infected group with S. typhi: It was showed a multifocal microabscesses consisted of aggregates of neutrophils in the focal area of necrosis, which was evident during 7th day and gradually transform into granulomas on 14th day postinoculation. 3. Transfer factor recipient and challenge infection group: It was showed well developed granulomatous reactions, which indicate an emergence of cellular immunity (delayed type hypersensitivity reaction). These granulomas were more evident on 7th day and slightly regressed on 14th day postinoculation; providing a transfer factor role in tissue reaction and termination of infection.
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2. Lawrence, H. S. (1974) Transfer factor in cellular immunity, New York: The Harvey Lectures, Series 68. Academic press, 239.
3. Fudenberg, H. H and Pizza, G. (1993) Transfer factor: New frontiers. In: Progress in Drug Research 42; Jucker E. ed. Basel Switzerland: Birkhauser verlag, 309-398,1994.
4. Petersen, E. A., Greenberg, L. E. Manzara, T. and Kirkpatrick, C.H. (1981) Murine transfer factor.1. Description of the model and evidence for specificity .J. Immunol. 126: 2480-2484.
5. Miles, A. A. and Misra, S.S. (1938) The estimation of the bacterial power of the blood. J. Hyg. 38:732-748.
6. Alvarez-Thull,L.and Kirkpatrick, C.H. (1996)Profiles of cytokine Production in recipiens of transfer factor. Biotherapy, 9: 55-59.
7. AL- Joboury, K. H.; Makkawi, T. A.; Khalifa, A. K and AL-Falluji, M.M. (2000) Typhoid fever:Pathological findings associated with Salmonella typhi infection in white mice. Proceeding of 5th Med. Conf. Coll. and dentistry, AL Anbar Univ. 17-21, 2000-2001.
8. Nakoneczna, I and HSU, H. S (1980) The comparative histopathogy of primary and secondary lesions in murine salmonellosis. Br. J. Exp. Pathol.61: 76-84.
9. Nakoneczna, I and HSU,H. S. (1983) Histopathological study of protective immunity against murine salmonellosis induced by killed vaccine.Infect, and
Immun.39: 423-430.
10. AL-Joboury, K. H. (2000a) A study on the bacterial dissemination and experimental pathology of Salmonella paratyphi B infection in white mice. Iraq J.Vet. Med. 24: 212-229.
11. AL-Joboury, K. H. (2000) A study on the bacterial dissemination and experimental pathology of Salmonella paratyphi A infection in white mice. Accepted, Iraqi J of Med. Sci.