The role of melatonin in maintenance of immunological internal environment
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Published:
Jun 28, 2003
Keywords:
melatonin, immunological
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Abstract
Melatonin hormone secretes from the pineal gland during dark period. This study was designed to investigate the effect of daily melatonin administration to chicks on some physiological parameters A total of fifty fawbro chicks of one day old were divided into two groups. The first group was given melatonin orally at a dose of 12ug/100g body weight daily for eight weeks and the other group was used as a control. During this experimental work the following parameters were studied. Daily feed and water intake, body temperature before and after melatonin administration with a general observation of chick's behaviour. Blood samples were collected weekly to study some parameters (total red blood cells, hemoglobin content, packed cell volume and differential leukocytic count).
The results showed that, melatonin caused a drop of body temperature with relaxation and sleeping of chicks up to three hours after its administration. This period was accompanied by depression of feed and water intake. Total RBCs count, Hb, PCV, and lymphocytes were significantly increased with a decrease in heterophil / lymphocyte ratio.
In conclusion, results of this investigation indicate that melatonin causes calming and sleeping of chicks and improves their feed conversion ratio.These results appear to be the first indication that melatonin does play an important role in immunity and improvement of blood picture. These effects were suggested to be due to the immuno – enhancing and anti-stress actio melatonin.
The results showed that, melatonin caused a drop of body temperature with relaxation and sleeping of chicks up to three hours after its administration. This period was accompanied by depression of feed and water intake. Total RBCs count, Hb, PCV, and lymphocytes were significantly increased with a decrease in heterophil / lymphocyte ratio.
In conclusion, results of this investigation indicate that melatonin causes calming and sleeping of chicks and improves their feed conversion ratio.These results appear to be the first indication that melatonin does play an important role in immunity and improvement of blood picture. These effects were suggested to be due to the immuno – enhancing and anti-stress actio melatonin.
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How to Cite
The role of melatonin in maintenance of immunological internal environment. (2003). The Iraqi Journal of Veterinary Medicine, 27(1), 208-215. https://doi.org/10.30539/ijvm.v27i1.1111
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Articles
How to Cite
The role of melatonin in maintenance of immunological internal environment. (2003). The Iraqi Journal of Veterinary Medicine, 27(1), 208-215. https://doi.org/10.30539/ijvm.v27i1.1111
References
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4. Lisson, P.; Tanic, G.; Brani, S.; Crispino, S.; Paolovossi, F.; Rorelli, F.; Coane, G. and Fraschini, F. (1988). Melatonin increase as predictor for tumor objective response to chemotherapy in advanced cancer patient. Tumor 74(3): 339-346.
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6. Campbell, T.W. (1988). Avian hematology and histology. 1* ed. Iowa state Uiversity press/Awes.
7. Varley, H.Growenlock, A. and Bell, M. (1980). Practical clinical Biochemistry .5th Ed. London. William, Medical book Ltd.
8. Pang, S.F.; Ralph, C.L. and Petrozza, J.A. (1976). Effect of melatonin administration and pinealectomy on the electroencephalogram of the chicken brain. Life Sci.18: 961-966.
9. Liou, S.S.; Cogburn, L.A.; Biellier, H.V.C. (1987). Photoperiodicregulation of plasma melatonin level in laying chicken (Gallus domesticus). Gen.Comp.Endocrinol.67 (2): 221-226.
10. Habib, A.A.W. (2000). The effect of melatonin hormone at day on some physiological characters of broilers. M.Sc thesis. College of Veterinary Medicine-University of Baghdad.
11. Tweist, G; and Smith, C. J. (1970). Circadian rhythm on blood glucose level of chickens. Comp. Biochemist. Physical 32:371-375.
12. Mcfarland, L.Z.; Wilson, W.O. and Winget, C.M. (1969). Response of the chicken pineal gland, blood and reproductive organs to darkness. Poult.Sci. 48:903-907
13. Montilla, P. L.; Tunez, I.F.; Munoz, A.C.; Gascon, F.L.; Sovia, J.V. (1998). Protective role of melatonin and retinol palmitate in oxidative stress and hyperlipidemic nephropathy induced by adriamycin in rats. J. Pineal Res.25 (2): 86-93.
14. Kuhn, E.R.; Decuypere, E.; Coleu, L.M. and Michels, H. (1982). Post hatch growth and development of a circadian rhythm for thyroid hormone in chick incubated at different temperatures. Poult.Sci.61: 540-549.
15. Lewis, S.M. (1983). Erythropoiesis in “ Postgraduate hematology“. Ed. Hoffbrand and Lewis, medical books, Ltd., London, PP: 1-34.
16. Al-Azawi, T.S.S. (2000). The relation ship between thyroxin and calcium metabolism in laying hens. Iraqi. J. Agric. V5 n.6: 144 49.
17. Sturkie. (2000). Avian physiology 5th ed. Springer Verlag, New York, Inc.
18. Kassab, A.; Elowi, H.; Al-murrani, W. (2000). Heterophil to lymphocyte ratio under high and low temperature stress as a selection criterion for immune response against Newcastle antigen in chicken. IPAJ. of Agric.Res. 10(2):
2. Wilson, J.D. and Foster, D.W. (1985).”Williams textbook of Endocrinology”. W.B.Saunders company, Philadelphia.
3. Sharp, P.J.; Klandrof, K. and Lea, R.W. (1984). Influence of lighting cycle on daily rhythms in concentrations of plasma triiodothyronine and thyroxine in intact and pinealectomized immature broiler hens. J.Endocrinol.103: 337-345.
4. Lisson, P.; Tanic, G.; Brani, S.; Crispino, S.; Paolovossi, F.; Rorelli, F.; Coane, G. and Fraschini, F. (1988). Melatonin increase as predictor for tumor objective response to chemotherapy in advanced cancer patient. Tumor 74(3): 339-346.
5. Jumah,S.H.; and Al-Azawi,T.S.(2002).L-tryptophan importance in broilers accepted at the 27th World Veterinary Congress .Tunis, Tunisia .September,25-29
6. Campbell, T.W. (1988). Avian hematology and histology. 1* ed. Iowa state Uiversity press/Awes.
7. Varley, H.Growenlock, A. and Bell, M. (1980). Practical clinical Biochemistry .5th Ed. London. William, Medical book Ltd.
8. Pang, S.F.; Ralph, C.L. and Petrozza, J.A. (1976). Effect of melatonin administration and pinealectomy on the electroencephalogram of the chicken brain. Life Sci.18: 961-966.
9. Liou, S.S.; Cogburn, L.A.; Biellier, H.V.C. (1987). Photoperiodicregulation of plasma melatonin level in laying chicken (Gallus domesticus). Gen.Comp.Endocrinol.67 (2): 221-226.
10. Habib, A.A.W. (2000). The effect of melatonin hormone at day on some physiological characters of broilers. M.Sc thesis. College of Veterinary Medicine-University of Baghdad.
11. Tweist, G; and Smith, C. J. (1970). Circadian rhythm on blood glucose level of chickens. Comp. Biochemist. Physical 32:371-375.
12. Mcfarland, L.Z.; Wilson, W.O. and Winget, C.M. (1969). Response of the chicken pineal gland, blood and reproductive organs to darkness. Poult.Sci. 48:903-907
13. Montilla, P. L.; Tunez, I.F.; Munoz, A.C.; Gascon, F.L.; Sovia, J.V. (1998). Protective role of melatonin and retinol palmitate in oxidative stress and hyperlipidemic nephropathy induced by adriamycin in rats. J. Pineal Res.25 (2): 86-93.
14. Kuhn, E.R.; Decuypere, E.; Coleu, L.M. and Michels, H. (1982). Post hatch growth and development of a circadian rhythm for thyroid hormone in chick incubated at different temperatures. Poult.Sci.61: 540-549.
15. Lewis, S.M. (1983). Erythropoiesis in “ Postgraduate hematology“. Ed. Hoffbrand and Lewis, medical books, Ltd., London, PP: 1-34.
16. Al-Azawi, T.S.S. (2000). The relation ship between thyroxin and calcium metabolism in laying hens. Iraqi. J. Agric. V5 n.6: 144 49.
17. Sturkie. (2000). Avian physiology 5th ed. Springer Verlag, New York, Inc.
18. Kassab, A.; Elowi, H.; Al-murrani, W. (2000). Heterophil to lymphocyte ratio under high and low temperature stress as a selection criterion for immune response against Newcastle antigen in chicken. IPAJ. of Agric.Res. 10(2):