Cyproheptadine as Growth Promoter In Broiler Chickens
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Published:
Jun 28, 2003
Keywords:
Cyproheptadine, Broiler Chickens, histamine, serotonine
Main Article Content
Abstract
Cyproheptadine hydrochloride is a very high potent histamine and serotonine antagonist. This study was conducted to investigate the role of cyproheptadine on feed intake, body weight gain, feed conversion ratio, serum total protein, cholesterol and glucose. Red blood cells (RBC), Hemoglobin (Hb), Packed Cell Volume (PCV) and differential leukocytic count in blood of chickens were also estimated. A total of 60 one-day-old Fabro chicks were randomly divided into 2 groups. One group was received cyproheptadine at a rate of 10 ug / 100g body weight daily for eight weeks and the second group was used as a control.
The results revealed that cyproheptadine could stimulate feed intake and improve body weight gain in chickens. Erythrocyte count, hemoglobin content and PCV where increased significantly in these chickens accompanied by an increase in percentage of lymphocytes with a significant decrease in percentage of heterophiles and H / L ratio. This drug also reduces the total protein, cholesterol and glucose in serum.
The results revealed that cyproheptadine could stimulate feed intake and improve body weight gain in chickens. Erythrocyte count, hemoglobin content and PCV where increased significantly in these chickens accompanied by an increase in percentage of lymphocytes with a significant decrease in percentage of heterophiles and H / L ratio. This drug also reduces the total protein, cholesterol and glucose in serum.
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Cyproheptadine as Growth Promoter In Broiler Chickens. (2003). The Iraqi Journal of Veterinary Medicine, 27(1), 191-201. https://doi.org/10.30539/ijvm.v27i1.1109
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Articles
How to Cite
Cyproheptadine as Growth Promoter In Broiler Chickens. (2003). The Iraqi Journal of Veterinary Medicine, 27(1), 191-201. https://doi.org/10.30539/ijvm.v27i1.1109
References
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3. Graudins, A.; Stearman, A. and Chan, B. (1998). Treatment ofserotonine syndrome with cyproheptadine is the result of excess stimulation of central nervous 5HT. J. Emerg - Med. 16 (4): 615-619.
4. Lavenstein, A.F.; Dacaney, E.P.; Lasagna, L. and Van Metre, T.E. (1962). Effect of cyproheptadine on asthmatic children. J. Amer Med. Ass. 180 : 912-916.
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6. Hening, C.W.; Harston, C.T. And Dunlap, W.P. (1980). Blockade of the melatonin potentiation of tonic immobility in chickens by methysergide and cyproheptadine. Behavioural and Neural Biology. 29 : 372 - 378.
7. Anderson, J.M.; Sugerman, K.S.; Lockhart, J.R. and Weinberg, W.A. (1997). Effective prophylactic therapy for cyclic vomiting syndrome in children using cyproheptadine. Pediatrics. 100 (6): 977 - 981.
8. Sakakibara, R; Fukutake, I; Kita, K and Hattor, I. (1996). Treatment of erythromelagia with cyproheptadine J. Auton. Nerv. Syst. 58 (1-2): 121 - 122.
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12. Dubowski, K.M. (1976). An 0 - toluidin method for body-fluid glucose determination in: " Fundamental of Clinical Chemistry". P: 251. ed. Tiefz, N.W. and Saunders, W.B. Companey Philadelphia.
13. Steel R. G and Torrie, J.H. (1980). " Principles and Procedures of statistics. A biometrical approach ". 2nd. ed. McGraw. Hill Book Co. N.Y.
14. Chakrabarty, A.S.; Pillai, R.V.; Anand, B.K. and Singh, B. (1967). Effect of cyproheptadine on the electrical activity of the hypothalamic feeding centres. Brain Res. 6: 561 - 569.
15. Sturkie, P.D. (2000). " Avain physiology". 5th. ed. Springer Verlag. N.Y.
16. Prelusky, D. B. Rotter, B. A. Thompson, B. K. and Trenholm, H. L. (1997). Effect of the appetite stimulant cyproheptadine on deoxynivalenol - induced reduction in feed consumption and weight gain in the mouse. J. Environ. Sci. Health B. 32 (3). 429 - 448.
17. Mercado - Asis, L.B.; Yanovski, J.A.; Tracer, H.L.; Chick, C.L.; Cutler, G.B. (1997). Acute effects of Bromocriptine, cyproheptadine and Valproic acid on plasma adrenocorticotropin secretion in Nelson's syndrome. J. Clin. Endocrino. Meta. 82 (2): 514-517.
18. Isobe, T. and Lillehoj, H. S. (1992). Effects of corticosteroids on lymphocyte subpopulations and lymphokine secretion in chickens. Avian Dis. 36:590 - 596.
19. Katz,L. M. Nathan, L. Kuhn, Cm. Schanberg, S. M. (1996). Inhibition of G. H. in maternal separation may be mediated through altered serotonergic activity of 5 - HT2A and 5-HT2C receptors. Psychoneuroendocrinology 21. (2). 219-235.
20. Drash, A.; Elliott, J.; Langs, H.; Lavenstein A.F. and Cooke, R.E. (1966). The effect of cyproheptadine on carbohydrate metabolism. Clin. Pharmacol. Thr. 7: 340 - 346.
2. Suh, H.W; Song, D.K; Choi, Y.S; Kirn, Y.H. (1996). Effects of intrathecally injected histamine receptors antagonists on the antinociception induced by morphine. Neuropeptides. 30 (5): 485 - 490.
3. Graudins, A.; Stearman, A. and Chan, B. (1998). Treatment ofserotonine syndrome with cyproheptadine is the result of excess stimulation of central nervous 5HT. J. Emerg - Med. 16 (4): 615-619.
4. Lavenstein, A.F.; Dacaney, E.P.; Lasagna, L. and Van Metre, T.E. (1962). Effect of cyproheptadine on asthmatic children. J. Amer Med. Ass. 180 : 912-916.
5. Penfold, J.L. (1971). Effect of cyproheptadine and a multivitamine preparation on appetite stimulation, weight gain and linear growth; A clinical trial of 40 children. Med. J. Aust. 1; 307 - 310.
6. Hening, C.W.; Harston, C.T. And Dunlap, W.P. (1980). Blockade of the melatonin potentiation of tonic immobility in chickens by methysergide and cyproheptadine. Behavioural and Neural Biology. 29 : 372 - 378.
7. Anderson, J.M.; Sugerman, K.S.; Lockhart, J.R. and Weinberg, W.A. (1997). Effective prophylactic therapy for cyclic vomiting syndrome in children using cyproheptadine. Pediatrics. 100 (6): 977 - 981.
8. Sakakibara, R; Fukutake, I; Kita, K and Hattor, I. (1996). Treatment of erythromelagia with cyproheptadine J. Auton. Nerv. Syst. 58 (1-2): 121 - 122.
9. Campbell, T.W. (1988). " Avian haematology and cytology". 1st ed. Iowa state University Press / Awes.
10. Wotton, I.D. (1964). " Micro Analysis : - Medical Biochemistry". 4th. Ed. J. and A. Churchill, Ltd. London WI.
11. Franey, R.J. and Eliac A. (1968). Semm cholesterol measurement based on ethanol extraction and ferric - chloride - sulfuric acid. Clinical Chemistry Acts. 21:255 - 263.
12. Dubowski, K.M. (1976). An 0 - toluidin method for body-fluid glucose determination in: " Fundamental of Clinical Chemistry". P: 251. ed. Tiefz, N.W. and Saunders, W.B. Companey Philadelphia.
13. Steel R. G and Torrie, J.H. (1980). " Principles and Procedures of statistics. A biometrical approach ". 2nd. ed. McGraw. Hill Book Co. N.Y.
14. Chakrabarty, A.S.; Pillai, R.V.; Anand, B.K. and Singh, B. (1967). Effect of cyproheptadine on the electrical activity of the hypothalamic feeding centres. Brain Res. 6: 561 - 569.
15. Sturkie, P.D. (2000). " Avain physiology". 5th. ed. Springer Verlag. N.Y.
16. Prelusky, D. B. Rotter, B. A. Thompson, B. K. and Trenholm, H. L. (1997). Effect of the appetite stimulant cyproheptadine on deoxynivalenol - induced reduction in feed consumption and weight gain in the mouse. J. Environ. Sci. Health B. 32 (3). 429 - 448.
17. Mercado - Asis, L.B.; Yanovski, J.A.; Tracer, H.L.; Chick, C.L.; Cutler, G.B. (1997). Acute effects of Bromocriptine, cyproheptadine and Valproic acid on plasma adrenocorticotropin secretion in Nelson's syndrome. J. Clin. Endocrino. Meta. 82 (2): 514-517.
18. Isobe, T. and Lillehoj, H. S. (1992). Effects of corticosteroids on lymphocyte subpopulations and lymphokine secretion in chickens. Avian Dis. 36:590 - 596.
19. Katz,L. M. Nathan, L. Kuhn, Cm. Schanberg, S. M. (1996). Inhibition of G. H. in maternal separation may be mediated through altered serotonergic activity of 5 - HT2A and 5-HT2C receptors. Psychoneuroendocrinology 21. (2). 219-235.
20. Drash, A.; Elliott, J.; Langs, H.; Lavenstein A.F. and Cooke, R.E. (1966). The effect of cyproheptadine on carbohydrate metabolism. Clin. Pharmacol. Thr. 7: 340 - 346.