The effect of candida albicans on some blood and biochemical parameters in laboratory mice . Hanan Abdel Reda Mohammed , Iqbal Abdel Aziz H A Zam , Mohammed Hassan Khadr

Abstract

In the present study , 32 white mice Balb /C (two months age ) were used ,there
were divided into four equal groups . Three groups were injected with fungal
suspention of candida albicans in doses of 1x106 ,1x108 and 3x108 cell/ml
,whereas the fourth group was regarded as control and injected with 0.5 ml
normal saline solution . All were dissected after 6 days of injection to study the
physiological effect of the yeast on blood , which include RBCand WBC count ,
Hb concentration and PCV ratio . And on biochemical content which
include the determination of protein , glycogen and cholestrol in liver ,kidney
and muscles .
The results showed that the number of RBC were decreased ,while WBC
were increased in the injected mice ,but there were no signifficant effect on
PCV and Hb . On the other hand ,cholestrol values were decreased significantly
in the injected mice in comparison with control,but this decrease was varied in
different tissues (P>0.01).The value was lower in liver ,whereas no signifficant
difference was found between Kidney and muscles . Protein values were not
signifficantly different in comparison with control , but it was different among
tissue studied .muscles was the highest value and the liver was lowest .
Glycogen decreased signifficantly in comparison with control ,but not among
tissues.